CNC Internal Newsletter
Issue 1 | July 2017

Publications June | July

o   A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.
Gonçalves D, et al. Neuropharmacology. 2017 Jul 19.
o   Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis.
Santarino IB, et al. Sci Rep. 2017 Jul 19.
o   Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software.
Perestrelo T, et al. Stem Cell Reports. 2017 Jul 3.
o   Lack of Additive Effects of Resveratrol and Energy Restriction in the Treatment of Hepatic Steatosis in Rats.
Milton-Laskibar I, et al. Nutrients. 2017 Jul 11.
o   Glioblastoma entities express subtle differences in molecular composition and response to treatment.
Balça-Silva J, et al.  Oncol Rep. 2017 Jul 7.

o   Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases.
Rufino-Ramos D, et al. J Control Release. 2017 Jul 4.
o   Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation.
Figueiredo SAC, et al. Eur J Med Chem. 2017 Jun 16.
o   Targeted Approach for Proteomic Analysis of a Hidden Membrane Protein.
Martins-Marques T, et al. Methods Mol Biol. 2017.
o   Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles.
Santos T, et al. Acta Biomater. 2017 Jun 30.
o   Mitochondrial biology in cancer stem cells.
Loureiro R, et al.

Semin Cancer Biol. 2017 Jun 30.
o   Chronic coffee consumption and respiratory disease: A systematic review.
Alfaro TM, et al. Clin Respir J. 2017 Jul 3.

o   New multilocus genotypes of Giardia lamblia human isolates.
Faria CP, et al. Infect Genet Evol. 2017 Jun 29.


o   Dendritic cell-based immunotherapy: a basic review and recent advances.
Constantino J, et al. Immunol Res. 2017 Jun 28.

o   The Expression of Connexins and SOX2 Reflects the Plasticity of Glioma Stem-Like Cells.
Balça-Silva J, et al. Transl Oncol. 2017 Jun 24.
o   S-nitrosylation of Ras mediates nitric oxide dependent post-injury neurogenesis in a seizure model.
Santos AI, et al. Antioxid Redox Signal. 2017 Jun 24.

o   Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF.
Martins LF, et al. Sci Rep. 2017 Jun 23.

o   Polyphenolic characterisation and bioactivity of an Oxalis pes-caprae L. leaf extract.
Gaspar MC, et al. Nat Prod Res. 2017 Jun 18.
o   Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes.
Gouveia PJ, et al. Biomaterials. 2017 Sep.
o   The Inclusion of Chitosan in Poly-ε-caprolactone Nanoparticles: Impact on the Delivery System Characteristics and on the Adsorbed Ovalbumin Secondary Structure.
Jesus S, et al. AAPS PharmSciTech. 2017 Jun 13.
o   Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats.
Ferreira A, et al. Food Chem Toxicol. 2017 Aug.
o   Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats.
Candeias E, et al. Mol Neurobiol. 2017 Jun 2.
o   Disconnection as a mechanism for social cognition impairment in multiple sclerosis.
Batista S, et al. Neurology. 2017 Jul 4.

o Obstructive Sleep Apnea and Hallmarks of Aging.
Gaspar LS, et al. Trends Mol Med. 2017 Jul 21.


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Events @ CNC
2nd JPND ESMI Meeting at Pólo I | 22 and 23 May
Participation at the annual meeting of the European project “European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative”
Partnership: Luís Pereira de Almeida group

6th Beer for Thought at UC-Biotech
| 27 July [see here]

6th Beer for Thought flyer
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Scientific Meetings and Events
Lufada do Atlântico International Conference | 26 – 25 May, Angra do Heroísmo, Azores (Portugal)
Participation of Cláudia Cavadas – “Searching for obstructive sleep apnea molecular biomarkers”
[see here]

Ecsite Annual Conference 2017 | 15 – 17 June, Oporto (Portugal)
CNC representation during the 28th edition of the European Network of Science Centers and Museums (Ecsite), which links science communication professionals.

Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications | 18 - 24 June, Figueira da Foz (Portugal)
Organized by Paulo Oliveira, Ana Urbano and their research teams [see here]

Encontro Ciência 2017 | 3 – 5 July –, Lisbon (Portugal)
CNC representation during the 3rd edition of the annual meeting of Science and Technology in Portugal. [see here]

2nd JPND ModelPolyQ Meeting | 4 – 5 July, Strasbourg (France)
Participation at the annual meeting of the European project “Advanced models of polyglutamine disorders (Huntington’s disease, SCA3 and SCA7) - ModelPOlyQ”
Coordination by Luís Pereira de Almeida
[see here]
Ciência 2017
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Awards / Honors

Research Grant Edgar Cruz e Silva - Santa Casa da Misericórdia de Lisboa and Grupo de Estudos de Envelhecimento Cerebral e Demências (GEECD)
Project: “New BACE1 inhibitors for the treatment of Alzheimer's disease: an approach for the development of effective and safe substrate-selective inhibitors". P.I.: Armanda Santos

Valorização Estâncias Termais da Região Centro - Caracterização do potencial bioativo dos recursos hídricos termais da Região
Project: “Estudo das propriedades terapêuticas das águas termais – dermocosmética” | P.I.: Teresa Cruz, Co-P.I.: Cláudia Pereira

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Public Engagement in Science
Noite dos Mistérios| | 24 June - at Museu da Ciência da Universidade de Coimbra [see photos]

Hands-on activities with children
| 6 July - at Museu da Água de Coimbra [see photos]

Public awareness at NOS Alive music festival | 6 – 8 July, collaboration with Maratona da Saúde [see photos]

Ciência às Seis” | 11 July, at Rómulo – Centro de Ciência Viva
Algumas notas sobre Reprodução e Células Estaminais: da investigação à ética e à comunicação de ciência” by João Ramalho-Santos [see photos]

UC dos Pequenitos” | 13 July, at CNC
Hands-on activities with children inserted in the summer program from Turismo da Universidade de Coimbra
[see photos]
Museu da Água
NOS Alive festival
Ciência Viva no Verão em Rede | 17 – 31 July, at Café Santa Cruz, collaboration with Rómulo – Centro de Ciência Viva:

- “Ciência na Rua” – hands-on activities with the public | 17 – 31 July

- “Ciência ao Luar” – scientific cafes: [More information here]
18 July - “Investigação Biomédica” – Catarina Resende Oliveira e Miguel Castelo-Branco
25 July - “Indústria BIOTECH” – Carlos Faro e Luís Pereira de Almeida

Students internships | 18 – 20 July, in collaboration with IEC (Instituto de Educação e Cidadania)

Ciência Viva no Laboratório – Ocupação Científica de Jovens nas Férias | 24 – 28 July Highschool Students internships [see photos]

We’re getting social. Launch of LinkedIn, Instagram, Twitter and Google+ accounts. Find us also on Facebook and YouTube.

Ciência na rua
Ciência ao luar
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Ciência viva no laboratório
CNC on the News
News about the International Conference “Lufada do Atlântico”, with Cláudia Cavadas participation (“Searching for obstructive sleep apnea molecular biomarkers”) – Atlântico Expresso, 12 June. Read here.

News about the paper "Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF". (Martins, et al.2017). found the list here.

News about the paper "Concerns that sleep apnea could impact healthspan." (Gaspar et al, 2017). Read here and here.

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Research Grants:

·Three Master positions - Project: “EU H2020 Metafluidics - Advanced toolbox for rapid and cost-effective functional metagenomic screening - microbiology meets microfluidics.
Two positions in Microbiology (Applications: 20 July – 6 August)
One position in Bioinformatics (Applications: 20 July – 6 August)

·One Master position – Project: “Glycerol as an alternative ingredient for fish feed potential for aqualculture
Applications: 3 – 17 August

·One Pos-Doctoral position – Project: “CANCEL_STEM: Tackling cancer stem cells: a challenge and an opportunity to advance in anti-cancer therapy.
Applications: 3 – 17 August

·One Master position – Project: “Role of astrocytes in memory control - focus on adenosine A2A receptors
Applications: until 29 August

·One Master position – Project: “Small proteasome inhibitory molecules: a step forward in the discovery of antitumor drugs"
Applications: 25 July – 2 September

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New faces | New roles

Ana Teresa Viegas
Science Communication Office
Digital Communication and Educational projects
Carla Veríssimo
Quality Assurance Unit Responsible
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What will happen...
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Science Communication Office | Ana Teresa Viegas, Sara Varela Amaral, Adalberto Fernandes, Cláudia Cavadas (Coordinator)
Design and Layout:

Lia Lopes and Ana Sofia Mergulhão